Pharmaceutical Steroid Exemestane Aromasin For Antitumor CAS
| CAS: | 107868-30-4 | Synonym: | Aromasin; Exemestan |
|---|---|---|---|
| MF: | C20H24O2 | MW: | 296.4 |
| Appearance: | White Crystalline Powder | Use: | Used To Fight Breast Cancer |
Pharmaceutical Steroid Exemestane Aromasin For Antitumor CAS 107868-30-4
Quick Detail
| Product Name |
Exemestane |
| Synonym |
Aromasin;Exemestan;Exemestane |
| CAS |
107868-30-4 |
| MF |
C20H24O2 |
| MW |
296.4 |
| Melting Point |
155.13°C |
| Solubility |
DMSO: ≥20mg/mL |
| Appearance |
White crystalline powder |
| Standard |
Enterprise Standard |
| Usage |
Aromasin is used to fight breast cancer and raise testosterone in the body |
Description
Exemestane is an aromatase inhibitor. This means it blocks the enzyme aromatase (found in the body's muscle, skin, breast and fat), which is used to convert androgens (hormones produced by the adrenal glands) into estrogen. In the absence of estrogen, tumors dependent on this hormone for growth will shrink.
Exemestanes Aromasin is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." By being structurally similar to enzyme targets, Exemestanes Aromasin permanently binds to the enzymes, preventing them from converting androgen into estrogen.
Application
Aromasin is used to fight breast cancer and raise testosterone in the body. Exemestane blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.
Exemestane (Aromasin) is a drug used to treat breast cancer. It is a member of the class of drugs known as aromatase inhibitors. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive, hormonally-responsive, or hormone-receptor-positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers.
Specification
| Item | Specification |
Result |
| Description | White Crystalline Powder |
White Powder |
| Identification | Positive |
Positive |
| Assay(by HPLC) | 98.0~102.0% |
98.64% |
| Absorbance(E1cm) | 465~495 |
482.5 |
| Melting Point | 191~195°C |
193.5~195.0°C |
| Loss On Drying | 0.5%max |
0.19% |
| Specific Rotation | +288°~ +298° |
+290.2° |
| Residue On Ignition | 0.1%max |
0.03% |
| Related Substances | Total:1.5%max |
<1.3% |
| Single:0.5%max |
<0.4% |
|
| Residue Solvents | 0.2%max |
0.10% |
| Heavy Metals | 20PPm max |
<10PPm |
Dosage
This is dependent on the individual and, also, the amount of aromatizing compounds the person is running. Generally, a good starting dose is 12.5mg ED (every day) or 25mg EOD (every other day). The user must utilize blood work to see how their body is reacting at the starting dosage they choose and then adjust as needed. Experienced anabolic steroid users will usually find a dose they like and stick to it with no problems. As I said already, if you start noticing joint issues then the dose should be lowered; on the other hand, if you start noticing any estrogen related sides, such as puffy or sensitive breasts or water retention, it's time to increase the dosage.
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